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Project AD Estro Pro+ — DIM, Calcium D-Glucarate and I3C for Estrogen Metabolism

Project AD Estro Pro+A capsule formula built on DIM, calcium D-glucarate, indole-3-carbinol and KSM-66 ashwagandha, intended to support the body's normal estrogen metabolism and clearance pathways.Before anything else: hormones are not something to adjust on guesswork. If you think your hormone levels are off, that is a blood test and a conversation with your doctor, not a shelf decision. This product supports normal metabolic pathways; it is not a treatment for anything, and we would rather say so plainly.What these ingredients actually doThis is worth getting right, because the marketing across this category describes something different from the mechanism.Your body produces estrogen, metabolises it into various forms, and clears it. These ingredients act on the metabolism and clearance steps — not on production. Indole-3-Carbinol (200mg) — a compound from cruciferous vegetables. In stomach acid it converts to DIM, which is why the two are related. It influences which pathway estrogen is metabolised down DIM (300mg) — diindolylmethane, the conversion product of I3C. It shifts estrogen metabolism toward the 2-hydroxy pathway rather than the 16-alpha-hydroxy pathway. This is a genuine, documented effect on estrogen metabolism Calcium D-Glucarate (500mg) — supports the elimination step. Once the liver conjugates hormones for excretion, a gut enzyme called beta-glucuronidase can un-conjugate some of them, allowing reabsorption. Calcium D-glucarate inhibits that enzyme, so more of what was marked for elimination actually leaves Chrysin — a flavonoid. See the honest note below KSM-66 Ashwagandha — a clinically studied adaptogen, included for stress response rather than estrogen directly Boron (10mg), Zinc (15mg), Vitamin B6 (50mg), Folate, Vitamin E, Calcium — cofactors in hormone metabolism and methylation BioPerine — black pepper extract for absorptionNote that I3C and DIM overlap. Since I3C converts to DIM in the stomach, including both is partly redundant — though it does spread the delivery.The honest note on chrysinChrysin is the ingredient most often named as the "natural aromatase inhibitor" in products like this. It does inhibit aromatase in laboratory studies.The problem is oral bioavailability. Chrysin is poorly absorbed and rapidly metabolised, and human studies have generally failed to show meaningful effects on hormone levels. The BioPerine here is partly there to address absorption, but the evidence remains weak.We would rather tell you that than let chrysin carry the page. The DIM, I3C and calcium D-glucarate mechanisms are the better-supported parts of this formula, and they work on metabolism and clearance rather than on blocking production.⚠ Not for tested athletesAromatase inhibitors and anti-estrogenic agents are prohibited under WADA category S4 (Hormone and Metabolic Modulators).This product is marketed as a natural aromatase inhibitor. Whether the individual compounds would trigger a positive test is a separate question from whether using a product marketed this way is advisable if you compete — and our answer is that it is not.If you are subject to any testing, do not use this. Ask us and we will point you to something certified.⚠ Other important cautionsSpeak to your doctor if you take any prescription medication. DIM and I3C affect liver enzyme systems involved in drug metabolism, which can change how medications behave.This is marketed for men and women. Estrogen plays essential roles in bone density, cardiovascular health and much else, in both sexes. Anyone considering a product that influences estrogen metabolism — particularly women, and particularly anyone on hormonal contraception or hormone therapy — should speak to their doctor first. This is not a casual purchase.Get bloodwork. You cannot feel your hormone levels. If hormones are genuinely your concern, a panel before and after is the only way to know anything, and it is a conversation worth having with a doctor regardless.Specs Calcium D-Glucarate500mg DIM300mg Indole-3-Carbinol200mg Vitamin B650mg Zinc15mg Boron10mg Also containsChrysin, KSM-66 ashwagandha, vitamin E, folate, calcium, BioPerine Capsules90 Vegan, gluten free, dairy free, soy freeYesHow to take it New users: 1 to 2 capsules daily. Experienced: 3 daily, one with each meal. Always with food. Maintenance is 1 to 2 capsules daily. Expect weeks, not days. Metabolic pathways shift gradually. Check your zinc and B6 totals if you also take a multivitamin or ZMA. B6 at 50mg is a substantial dose and it accumulates across products.Who this is for Adults already working with a doctor on hormone health who want supporting nutrition People willing to get bloodwork and actually measure Anyone who wants the cruciferous vegetable compounds without eating a kilogram of broccoli dailyWho this is not forAny tested athlete. See above.Anyone on prescription medication, hormonal contraception or hormone therapy, without speaking to their doctor.Anyone pregnant, nursing, or trying to conceive. Under 18 as well.Anyone using this instead of seeing a doctor. If you suspect a hormone problem, get tested. Symptoms attributed to hormones frequently have other causes, and a supplement will not identify which.And honestly: if the goal is looking leaner and drier, the answer is a caloric deficit and lower sodium, not a hormone product. That is what actually produces it, and we will tell you the same in the store.Stack it with: nothing else hormonal. Check your zinc and B6 totals across everything you take.Frequently asked questionsWhat does DIM do?Diindolylmethane shifts estrogen metabolism toward the 2-hydroxy pathway rather than the 16-alpha-hydroxy pathway. It acts on how estrogen is metabolised, not on how much is produced.What is calcium D-glucarate for?It inhibits beta-glucuronidase, a gut enzyme that can un-conjugate hormones the liver has already marked for excretion. Inhibiting it supports elimination of what was already destined to leave.Why does it contain both I3C and DIM?I3C converts to DIM in stomach acid, so they overlap. Including both spreads delivery, though it is partly redundant.Does chrysin work?It inhibits aromatase in laboratory studies, but oral bioavailability is poor and human studies have generally not shown meaningful hormonal effects. The better-supported ingredients here are DIM, I3C and calcium D-glucarate.Can I use it if I am drug tested?No. Aromatase inhibitors and anti-estrogenic agents fall under WADA category S4. Do not use this if you compete in a tested federation.Can women take it?It is marketed for both, but estrogen has essential roles in bone and cardiovascular health. Anyone considering this — particularly women, and anyone on contraception or hormone therapy — should speak to their doctor first.Will it raise my testosterone?This supports estrogen metabolism pathways. Treat any testosterone claim with caution, and if hormone levels are your genuine concern, get a blood test rather than guessing.How long before anything changes?Weeks. And you will not feel it — bloodwork is the only way to know. Read more

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PRODUCT LABEL

Project AD Estro Pro+

A capsule formula built on DIM, calcium D-glucarate, indole-3-carbinol and KSM-66 ashwagandha, intended to support the body's normal estrogen metabolism and clearance pathways.

Before anything else: hormones are not something to adjust on guesswork. If you think your hormone levels are off, that is a blood test and a conversation with your doctor, not a shelf decision. This product supports normal metabolic pathways; it is not a treatment for anything, and we would rather say so plainly.

What these ingredients actually do

This is worth getting right, because the marketing across this category describes something different from the mechanism.

Your body produces estrogen, metabolises it into various forms, and clears it. These ingredients act on the metabolism and clearance steps — not on production.

Indole-3-Carbinol (200mg) — a compound from cruciferous vegetables. In stomach acid it converts to DIM, which is why the two are related. It influences which pathway estrogen is metabolised down
DIM (300mg) — diindolylmethane, the conversion product of I3C. It shifts estrogen metabolism toward the 2-hydroxy pathway rather than the 16-alpha-hydroxy pathway. This is a genuine, documented effect on estrogen metabolism
Calcium D-Glucarate (500mg) — supports the elimination step. Once the liver conjugates hormones for excretion, a gut enzyme called beta-glucuronidase can un-conjugate some of them, allowing reabsorption. Calcium D-glucarate inhibits that enzyme, so more of what was marked for elimination actually leaves
Chrysin — a flavonoid. See the honest note below
KSM-66 Ashwagandha — a clinically studied adaptogen, included for stress response rather than estrogen directly
Boron (10mg), Zinc (15mg), Vitamin B6 (50mg), Folate, Vitamin E, Calcium — cofactors in hormone metabolism and methylation
BioPerine — black pepper extract for absorption

Note that I3C and DIM overlap. Since I3C converts to DIM in the stomach, including both is partly redundant — though it does spread the delivery.

The honest note on chrysin

Chrysin is the ingredient most often named as the "natural aromatase inhibitor" in products like this. It does inhibit aromatase in laboratory studies.

The problem is oral bioavailability. Chrysin is poorly absorbed and rapidly metabolised, and human studies have generally failed to show meaningful effects on hormone levels. The BioPerine here is partly there to address absorption, but the evidence remains weak.

We would rather tell you that than let chrysin carry the page. The DIM, I3C and calcium D-glucarate mechanisms are the better-supported parts of this formula, and they work on metabolism and clearance rather than on blocking production.

⚠ Not for tested athletes

Aromatase inhibitors and anti-estrogenic agents are prohibited under WADA category S4 (Hormone and Metabolic Modulators).

This product is marketed as a natural aromatase inhibitor. Whether the individual compounds would trigger a positive test is a separate question from whether using a product marketed this way is advisable if you compete — and our answer is that it is not.

If you are subject to any testing, do not use this. Ask us and we will point you to something certified.

⚠ Other important cautions

Speak to your doctor if you take any prescription medication. DIM and I3C affect liver enzyme systems involved in drug metabolism, which can change how medications behave.

This is marketed for men and women. Estrogen plays essential roles in bone density, cardiovascular health and much else, in both sexes. Anyone considering a product that influences estrogen metabolism — particularly women, and particularly anyone on hormonal contraception or hormone therapy — should speak to their doctor first. This is not a casual purchase.

Get bloodwork. You cannot feel your hormone levels. If hormones are genuinely your concern, a panel before and after is the only way to know anything, and it is a conversation worth having with a doctor regardless.

Specs

Calcium D-Glucarate	500mg
DIM	300mg
Indole-3-Carbinol	200mg
Vitamin B6	50mg
Zinc	15mg
Boron	10mg
Also contains	Chrysin, KSM-66 ashwagandha, vitamin E, folate, calcium, BioPerine
Capsules	90
Vegan, gluten free, dairy free, soy free	Yes

How to take it

New users: 1 to 2 capsules daily. Experienced: 3 daily, one with each meal.
Always with food.
Maintenance is 1 to 2 capsules daily.
Expect weeks, not days. Metabolic pathways shift gradually.
Check your zinc and B6 totals if you also take a multivitamin or ZMA. B6 at 50mg is a substantial dose and it accumulates across products.

Who this is for

Adults already working with a doctor on hormone health who want supporting nutrition
People willing to get bloodwork and actually measure
Anyone who wants the cruciferous vegetable compounds without eating a kilogram of broccoli daily

Who this is not for

Any tested athlete. See above.

Anyone on prescription medication, hormonal contraception or hormone therapy, without speaking to their doctor.

Anyone pregnant, nursing, or trying to conceive. Under 18 as well.

Anyone using this instead of seeing a doctor. If you suspect a hormone problem, get tested. Symptoms attributed to hormones frequently have other causes, and a supplement will not identify which.

And honestly: if the goal is looking leaner and drier, the answer is a caloric deficit and lower sodium, not a hormone product. That is what actually produces it, and we will tell you the same in the store.

Stack it with: nothing else hormonal. Check your zinc and B6 totals across everything you take.

Frequently asked questions

What does DIM do?
Diindolylmethane shifts estrogen metabolism toward the 2-hydroxy pathway rather than the 16-alpha-hydroxy pathway. It acts on how estrogen is metabolised, not on how much is produced.

What is calcium D-glucarate for?
It inhibits beta-glucuronidase, a gut enzyme that can un-conjugate hormones the liver has already marked for excretion. Inhibiting it supports elimination of what was already destined to leave.

Why does it contain both I3C and DIM?
I3C converts to DIM in stomach acid, so they overlap. Including both spreads delivery, though it is partly redundant.

Does chrysin work?
It inhibits aromatase in laboratory studies, but oral bioavailability is poor and human studies have generally not shown meaningful hormonal effects. The better-supported ingredients here are DIM, I3C and calcium D-glucarate.

Can I use it if I am drug tested?
No. Aromatase inhibitors and anti-estrogenic agents fall under WADA category S4. Do not use this if you compete in a tested federation.

Can women take it?
It is marketed for both, but estrogen has essential roles in bone and cardiovascular health. Anyone considering this — particularly women, and anyone on contraception or hormone therapy — should speak to their doctor first.

Will it raise my testosterone?
This supports estrogen metabolism pathways. Treat any testosterone claim with caution, and if hormone levels are your genuine concern, get a blood test rather than guessing.

How long before anything changes?
Weeks. And you will not feel it — bloodwork is the only way to know.